The Forschungskolleg Humanwissenschaften: EventsThursday, 29 June 2017, 17:00
Venue: Goethe-Universität, Campus Riedberg, Hörsaal B 1 im Biocenter (Adresse: Max-von-Laue-Straße 9, 60438 Frankfurt am Main)
Research project »Complexity in Science, Culture, and Society«
Christopher Dobson (University of Cambridge)
»Complexity in Protein Folding and Misfolding«
Christopher Dobson ist John Humphrey Plummer Professor of Chemical and Structural Biology an der University of Cambridge. Er wurde vor allem für seine Arbeiten zu Störungen der Proteinfaltung bekannt.
About the lecture
Protein folding is an essential step in the generation of evolved biological functionality within all living systems, and much is now understood about the underlying mechanism of this complex and ubiquitous process. Proteins can, however, misfold or fail to remain in their correctly folded states, and in some such cases this results in the formation of intractable aggregates known as amyloid fibrils. Interest in this phenomenon has developed with extraordinary rapidity in recent years, primarily because of the links between amyloid formation and a range of rapidly proliferating medical disorders. More than fifty diseases are now linked to this phenomenon and include neurological disorders such as Alzheimer’s disease, non-neuropathic organ specific disorders such as type II diabetes, and a range of systemic amyloidoses. This talk will illustrate how a combination of biophysical techniques has played a major role in recent dramatic advances in our knowledge of the structural and physical properties of the amyloid state, the kinetics and mechanism of its formation, the nature and origins of its links with disease, and the emerging opportunities for innovative approaches to therapeutic intervention. - Der Vortrag findet in englischer Sprache statt.
About the research project
Durchführuhng der Pilotphase mit freundlicher Unterstützung der Aventis Foundation.
Weitere Informationen: Dr. des. Elinor Schweighöfer, Projektkoordinatorin (firstname.lastname@example.org; Tel.: 06172 / 13977-14).
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